Herman Alfred (Al) Tyroler, MD, was a world-renowned cardiovascular disease epidemiologist. He was one of the primary scientists involved in developing collaborations between the U.S. and the Soviet Union on cardiovascular disease studies. He also was involved in the original proposal to conduct the Atherosclerosis Risk in Communities (ARIC) study. He was elected to the Institute of Medicine, National Academy of Sciences in 1980. Dr. Tyroler’s distinguished career at UNC spanned more than 40 years and established his reputation as an innovative scientist, a leader in public health, and a dedicated educator and mentor to numerous students and colleagues. Dr. Tyroler is remembered with affection and gratitude as a lifelong learner and a brilliant teacher who shaped the lives of those with whom he worked.