Mendelian Randomization

Jeremy Labrecque

According to Mendelian randomization lore, the idea behind MR was first dreamt up on a rainy Hawaiian beach by Dutch epidemiologist Martijn Katan and subsequently published in a 450-word commentary in the Lancet. Katan’s rationale was, if we know that the effect of cholesterol on cancer is hopelessly confounded, why not look instead at genetic variants that are associated with cholesterol? Read more