Alan R. Lifson

Since being described in 1976, Ebola virus has been responsible for multiple outbreaks, the largest of which occurred in West Africa during 2014–2016. Since 2018, another serious epidemic has been spreading in the Democratic Republic of Congo. Among strategies to help prevent and control such outbreaks has been development and implementation of a vaccine, a number of which have been in clinical trials, and one of which is currently being deployed in the DRC using a ‘ring’ approach. Evaluation of various vaccine candidates present a number of immunologic, clinical, epidemiologic and ethical challenges, many of which are discussed in these articles.

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