Cardiovascular
Relationship Between Body Mass Index and ADP MA (Maximum Amplitude) in Deep Vein Arterialization Patients Using TEG-PM Isabella Ferlini Cieri* Isabella Ferlini Cieri Adriana A. Rodriguez Alvarez1 Mounika Boya Leela Morená Shiv Sureshchandra Patel Andrea Nurko Anahita Dua
Background: Deep vein arterialization (DVA) represents an innovative therapeutic approach for patients with no-option critical limb-threatening ischemia and peripheral arterial disease (PAD). Understanding the complex relationship between patient characteristics and platelet function is crucial for optimizing procedural outcomes and reducing complications. Adenosine diphosphate maximum amplitude (ADP MA) measured by thromboelastography with platelet mapping (TEG-PM) is a key parameter that reflects the degree of platelet aggregation in response to ADP stimulation, providing valuable information about platelet reactivity. This study investigates the correlation between body mass index (BMI) and platelet function as measured by TEG-PM.
Methods: In a prospective single-center study of DVA patients (2020-2024), we conducted a detailed analysis of the correlation between BMI and ADP MA from TEG-PM measurements. Comprehensive descriptive statistics and Mann-Whitney test were performed to characterize the relationship between these parameters.
Results: Among 17 patients undergoing DVA procedures, BMI measurements (median 24.86 kg/m², IQR 23.09-28.40) and ADP MA values (median 56.90 mm, IQR 49.35-61.45) demonstrated significant variation. Statistical analysis revealed a strong and significant relationship between these parameters (p<0.001). The BMI measurements exhibited notably less variability (SD: 4.075) compared to ADP MA measurements (SD: 15.42), suggesting complex and multifaceted interactions between body mass and platelet function in this specialized patient population.
Conclusion: Our analysis reveals a significant relationship between BMI and TEG-PM parameters in DVA patients, potentially influencing perioperative assessment strategies. Further investigation in larger cohorts is warranted to validate these findings.
Keywords: Deep vein arterialization, thromboelastography, platelet mapping, body mass index, peripheral artery disease.
