Global Health
Trends in incidence of trigeminal neuralgia with inflammatory bowel disease in Taiwan: a 14-year long term descriptive study Ting-Fu Huang* Ting-Fu Huang Fu-Huang Lin Chien-An Sun Yu-Ching Chou
Trends in incidence of trigeminal neuralgia with inflammatory bowel disease in Taiwan: a 14-year long term descriptive study
Ting-Fu Huang1, Fu-Huang Lin1, Chien-An Sun2, Yu-Ching Chou1*
1School of Public Health, National Defense Medical Center, Taipei
2Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan
*Corresponding author: trishow@mail.ndmctsgh.edu.tw
Background: Both inflammatory bowel disease (IBD) and trigeminal neuralgia (TN) are rare diseases that significantly impact patients’ quality of life. Previous studies suggest that extraintestinal manifestations associated with IBD may explain the relationship between these two diseases, although evidence remains limited. This descriptive study examined the incidence of TN with IBD in a large-scale, population-based cohort in Taiwan.
Methods: From 2000 to 2013, about 66,489 new cases with IBD were identified in Taiwan’s National Health Insurance Research Database (NHIRD). Chi-square test was used for evaluating incidence rates in different sex, age groups and periods. For long term trends, we assessed the change in the incidence rates over 14 years by linear trend analysis.
Results: The incidence of TN among IBD patients increased from 4.50 per 10,000 person-years in 2000 to 70.73 per 10,000 person-years in 2013, with an average incidence of 51.12 per 10,000 person-years. The incidence rate was 35.90 among men and 64.87 among women per 10,000 person-years. When stratifying patients into five age groups, the incidence of TN per 10,000 person-years was as follows: 5.34 (ages 20–30), 6.08 (ages 30–40), 9.77 (ages 40–50), 9.81 (ages 50–60), and 14.41 (ages ≥ 60). As age increases, patients with IBD tend to have a higher incidence of TN.
Conclusion: Over the 14-year study period, the incidence of TN significantly impacted the quality of life of patients. Our findings, based on big data analysis, indicate a steady rise in TN incidence among IBD patients. Thus, the study to indicate a positive correlation between IBD and TN is needed.