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Women’s Health

Antenatal Depression and its Associated Factors: Findings from Kuwait Birth Cohort Study Abdullah Al-Taiar* Abdullah Al-Taiar Reem Al-Sabah Ali H. Ziyab Saeed Akhtar Majeda S. Hammoud

Background and objectives: Pregnant and postpartum women are at high risk of depression due to hormonal and biological changes. Antenatal depression is understudied compared to postpartum depression and its predictors remain highly controversial. The aim of this study was to estimate the prevalence of antenatal depression and investigate factors associated with this condition including vitamin D, folate and Vitamin B12 among participants in the Kuwait Birth Cohort Study.

Methods: Data collection occurred as part of the Kuwait birth cohort study in which pregnant women were recruited in the second and third trimester during antenatal care visits. Data on antenatal depression were collected using the Edinburgh Postnatal Depression Scale (EPDS), considering a score of ≥ 13 as indicator of depression. Logistic regression was used to investigate factors associated with antenatal depression.

Results: Of 1108 participants in the Kuwait Birth Cohort study, 1070(96.6%) completed the EPDS. The prevalence of antenatal depression was 21.03%(95%CI:18.62-23.59%) and 17.85%(95%CI:15.60-20.28%) as indicated by an EPDS ≥13 and EPDS ≥14, respectively.  In the multivariable analysis, passive smoking at home, experiencing stressful life events during pregnancy, and a lower level of vitamin B12 were identified as predisposing factors. Conversely, having desire for the pregnancy and consumption of fruits and vegetables were inversely associated with antenatal depression.

Conclusion: Approximately, one fifth of pregnant women had depression indicating the need to implement screening program for depression in pregnant women, a measure not systematically implemented in Kuwait. Specifically, screening efforts should focus on pregnant women with unintended pregnancies, exposure to passive smoking at home, and recent stressful live events.