Genetics
Genome-wide association study and post-GWAS analysis of serum adiponectin levels in 46,370 Korean individuals SUN HA JEE* SUN HA JEE JEE JEE JEE JEE JEE Yonsei University
Background:
Adiponectin is an important adipokine involved in lipid metabolism, insulin sensitivity and anti – inflammatory activities. While previous studies have been conducted in populations of European ancestry, there remains a significant lack of large-scale research in non-European cohorts.
Methods:
In this study, we performed a genome wide association study (GWAS) fine-mapping, and GCTA-COJO conditional analyses of plasma adiponectin levels in 46,370 Korean ancestry participants from the Korean Cancer Prevention Study II (KCPS2).
Results:
Among the 1,689 significant SNPs identified (p < 5e-8), 627 were mapped to 32 nearest using NCBI37 gene location file. Significant variants were located primarily on chromosome 16 and 3, with the most significant SNP, rs12051272 (p = 6.12e-440), residing within the CDH13 gene region. On chromosome 3, the top-associated SNP was rs11711353 (p = 1.1e-76), and rs12495941 showed the strongest signal within the ADIPOQ gene region (p = 4.39e-61). Further, variant rs12051272 was consistently indicated as having an independent effect on plasma adiponectin levels by fine-mapping and GCTA-COJO analyses. The effect of rs11711353 however appears to be influenced by neighbouring variants.
Conclusions:
The study replicates results from previous genetic studies, and provides a solid foundation for further analyses.The study replicates results from previous genetic studies, and provides a solid foundation for further analyses.
This study was supported by BasgenBio (2021-2026) and the National Cancer Center (HA21C0142).