Cancer
Association Between Dietary Intake of Advanced Glycation End-Products and Aggressive Prostate Cancer Among Black and White Men in the North Carolina-Louisiana Prostate Cancer Project Hadi Rashidi* Hadi Rashidi David P Turner Joseph Su Lenore Arab Jeannette T Bensen Ebonee N. Butler Laura Farnan Victoria Findlay James L. Mohler Tyler-Stukes, Gayle Susan E Steck
Background
Prostate cancer is the most common cancer and second leading cause of cancer-related mortality among men in the United States. Advanced glycation end-products (AGEs) are reactive metabolites formed endogenously but also consumed in processed food and foods that are cooked at high temperatures. Evidence from experimental animal studies show that AGEs are related to pathogenesis of various chronic diseases including cancer. However, the association between dietary AGEs and aggressive prostate cancer has yet to be examined.
Method
We analyzed data from the North Carolina – Louisiana Prostate Cancer Project (PCaP), a cross-sectional study of Black and White men diagnosed with prostate cancer. We included 1900 men, (901 Black and 991 White) in the analyses and defined aggressiveness as “high” (n=332) or “low/intermediate” (n=1568) based on clinical stage, Gleason grade, and prostate specific antigen at diagnosis. Dietary intake of AGEs was estimated from responses to the NCI-Diet History Questionnaire linked to the Uribarri et al. dietary AGE database. Multivariable logistic regression was used to determine the adjusted odds ratios and 95% confidence intervals for high-aggressive prostate cancer by tertile of AGE intake.
Result
Among dietary sources of AGEs, red meat products were major contributors, representing 23.4% of total AGE intake. In race-stratified analyses, a positive association between AGEs intake and high aggressive prostate cancer was observed for Black men (OR2nd vs 1st tertile= 1.42; CI, 0.88-2.29 and OR3rd vs 1st tertile=1.68; CI, 0.96-2.91) but not for White men (OR2nd vs 1st tertile = 0.88; CI, 0.56-1.38, OR3rd vs 1st tertile =0.75; CI, 0.39-1.41).
Conclusion
Based on study results, it appears that higher dietary AGEs intake is associated with increased odds of high aggressive prostate cancer among Black men. Future prospective studies are warranted to confirm this finding