Health Disparities
The association of medical mistrust, clinical trial knowledge, and perceived clinical trial risk with willingness to participate in health research among historically marginalized individuals living in New York City Isabel Curro* Isabel Curro Laura C Wyatt Yousra Yusuf Victoria Foster Sonia Sifuentes Perla Chebli Julie A Kranick Simona C Kwon Chau Trinh-Shevrin Madison N LeCroy
Background: Medical mistrust, clinical trial knowledge, and clinical trial risk impact research participation yet are rarely studied among racial and ethnic groups.
Methods: Data were from a cross-sectional community needs assessment (n=1812). Multinomial logistic regression models examined associations of medical mistrust, clinical trial knowledge, and clinical trial risk with willingness to participate in health research (Yes [ref], No, Unsure) among Chinese, Korean, South Asian, Haitian, Hispanic, and Southwest Asian and North African (SWANA) NYC residents. One model was run for each group. Further disaggregated findings for Hispanic subgroups will be presented.
Results: Overall, 46.1% of participants reported willingness to take part in health research, ranging from 35.8% (Chinese participants) to 58.7% (South Asian participants). More medical mistrust was associated with less willingness to participate for Chinese (OR: 1.06, 95%CI: 1.00, 1.12) and Hispanic (OR: 1.08, 95%CI: 1.01, 1.14) participants; more willingness for Haitian participants (OR: 0.87, 95%CI: 0.81, 0.94); more uncertainty on willingness for Korean (OR: 1.13, 95%CI: 1.05, 1.22), South Asian (OR: 1.07 95%CI: 1.01, 1.12), and Hispanic (OR: 1.10, 95%CI: 1.05, 1.16) participants; and less uncertainty for Haitian (OR: 0.91, 95%CI: 0.84, 0.99) and SWANA (OR: 0.91, 95%CI:0.86, 0.97) participants. Clinical trial knowledge is linked to more participation willingness for Haitian participants (OR: 2.77, 95%CI: 1.15, 6.65); less willingness for Chinese participants (OR: 0.55, 95%CI: 0.34, 0.88); and more uncertainty on willingness for South Asian (OR: 2.09, 95%CI: 1.07, 4.07), Hispanic (OR: 1.81, 95%CI: 1.05, 3.11), and SWANA (OR: 2.71, 95%CI: 1.21, 6.03) participants.
Conclusion: Willingness to participate in research and associations with mistrust, knowledge, and risk varied by group. Studying diverse groups can advance tailored engagement and equitable representation of underserved populations in research.