Cardiovascular
Association of Neighborhood Deprivation and Carotid Intima-Media Thickness in the Bogalusa Heart Study Cohort Jenilee Cueto* Jenilee Cueto Eunsun Gill Ileana De-Anda Duran Lydia Bazzano Alexander Kimbrough Shakira Suglia Maeve Wallace Emily Harville Kirsten Dorans
Introduction: Neighborhood deprivation, a measure of socioeconomic status, has been linked to cardiovascular and cardiometabolic diseases. The impact of neighborhood deprivation in rural areas and its association with subclinical cardiovascular disease is unclear.
Objective: To evaluate the association of neighborhood deprivation and carotid intima-media thickness (CIMT) among adults participating in the Bogalusa Heart Study (BHS).
Methods: Neighborhood deprivation was defined using the Area Deprivation Index (ADI), a factor-based deprivation index using 16 poverty, education, housing, and employment factors, and divided into quintiles. Two far-wall carotid intima-media measurements were obtained and averaged. Composite-CIMT was defined as the average of the segmental maximum CIMT. Participants with complete data (n=1104 after exclusions for missing data) were assessed for the association of their most recent ADI and CIMT in adulthood (measured 2013-2016) using linear regression, adjusting for age, sex, race, blood pressure, lipids, body mass index, smoking, alcohol use, employment, and education.
Results: The median age of the BHS cohort was 49 years (IQR 8.4). Fifty-eight percent were female, 36% were Black, and mean BMI was 31.3±7.7 kg/m2. Median CIMT was 0.87 (IQR 0.31). In the unadjusted model, mean CIMT significantly differed by ADI quintile (p=0.03). CIMT in the 4th quintile was 5% (95% CI -1 to 11%) higher compared to CIMT in the first quintile (p=0.07). In adjusted analyses, there was no association between ADI and CIMT and test for trend did not demonstrate linearity (p=0.4). Adjusted analyses stratified by age and race were also not significant.
Conclusion: There was no association between neighborhood deprivation and CIMT measured in midlife. Future research is needed to study the association of early-life ADI with CIMT and other markers of CVD risk.
