Nutrition/Obesity
The Association Between Visceral Obesity and Mild Cognitive Impairment Sujeong Han* Sujeong Han Jun-Young Lee Sung-il Cho Dae Jong Oh Dae Hyun Yoon
Objective
The aim of this study was to determine whether visceral obesity is a risk factor for Non-Amnestic Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment.
Methods
The data from the Seoul National University Hospital Healthcare System, Gangnam Center, from 2005-2020. The number of study subjects was 569 who underwent regular cognitive function test. Cox’s proportional hazard analysis was conducted to compare survival rates between visceral obesity and people without visceral obesity.
Results
The Kaplan-Meier survival curves for Non-Amnestic MCI(na-MCI) risk differed significantly between the obesity groups. The risk was significantly higher in the visceral obesity group than in the non-visceral obesity group (Log-rank p=0.014). After 2 years, the cumulative incidence of Non-Amnestic Mild Cognitive Impairment increases by at least 50%, and after 5 years it exceeds 60%. The adjusted Hazard ratio (HR) for Non-Amnestic Mild Cognitive Impairment in the subjects with visceral obesity was HR=1.43, 95% CI=1.10-1.86.
Conclusion
Our findings suggest that visceral obesity is associated with a higher risk of Non-Amnestic Mild Cognitive Impairment. It is important to consider whether visceral obesity after a Mild Cognitive Impairment diagnosis increases the risk of future dementia. Early detection of Mild Cognitive Impairment in obese individuals is important to prevent future cognitive decline.
Keywords Visceral obesity; Mild Cognitive Impairment; Older adults; Longitudinal; Survival analysis; Cox’s proportional hazard analysis