Reproductive
Ruminant-specific and ruminant-predominant fatty acid levels in relation to infertility treatment outcomes Xi Zhang* Xi Zhang Russ Hauser Lidia Minguez-Alarcon Jorge Chavarro
We evaluated the relation between circulating levels of odd-chain fatty acids and ruminant-predominant trans fat isomers, known biomarkers of dairy food intake, and outcomes of infertility treatment with Assisted Reproductive Technology (ART). Couples enrolled in the EARTH Study between 2004 and 2019 provided pre-treatment blood samples. We measured serum levels of fatty acid known to be exclusively (13:0, 15:0, 17:0, 19:0 and 23:0) or predominantly (16:1n-7t, 14:1n-5t) of ruminant origin using gas chromatography in these samples. The study outcome was live birth per initiated treatment cycle. Logistic regression models using cluster-weighed generalized estimating equations to account for repeated treatment cycles were used to estimate the odds of live birth, after accounting for potential confounders. The analysis include 306 women who completed 537 ART cycles of which 191 ended in a live birth. Serum odd chain fatty acids and ruminant-predominant trans fatty acids were positively related to dairy intake and unrelated to red meat intake. There was no association between serum odd chain or ruminant predominant fatty acids with the probability of live birth following infertility treatment with ART. The multivariable adjusted OR (95% CI) of live birth for women in increasing quartiles of serum odd chain fatty acids was 1 (ref), 1.02 (0.60, 1.73), 0.83 (0.49, 1.40) and 0.75 (0.44, 1.29). The corresponding estimates for increasing quartiles of ruminant predominant trans fatty acid levels were 1 (ref), 0.71 (0.43, 1.18), 0.86 (0.52, 1.42) and 1.06 (0.65, 1.74). These findings are not consistent with a strong beneficial or deleterious effect of dairy food consumption on outcomes of infertility treatment with ART.
Enter number 1736