Cardiovascular
Cardiovascular health and its association with all-cause dementia, parkinson’s disease and mortality among UK older adults: a multistate analysis Michael F. Georgescu* Michael Georgescu May A. Beydoun Jordan Weiss Jagdish Kubchandani Sri Banerjee Alyssa A. Gamaldo Michele K. Evans Alan B. Zonderman
Background: The study investigated the relationship between cardiovascular health (CVH), all-cause dementia, Parkinson’s disease (PD) and mortality, identifying associations and transitions.
Methods: Using data from the UK Biobank (n=269,816, Age = 60+y individuals, ≤15y follow-up).
We investigated the relationships between cardiovascular health and PD, dementia, and mortality using Cox Proportional Hazards with sequential covariate adjustment. Finally, we used multistate parametric models to identify health state transitions: healthy (state 1; dementia- and PD- free), PD (state 2; irrespective of dementia status), dementia (state 3; irrespective of PD status), death (state 4). Transition rates between the states were modeled using fully parametric Weibull regression.
Results: Full models found poor CVH associated with a 14% increased risk of all-cause dementia and 31% increased risk for all-cause mortality. Healthy and PD transition had no association; however, poor CVH and transition PD and death, Healthy and dementia, Healthy and death had a positive relationship. Transitions PD Dementia and Dementia Death was not associated with poor CVH z-score.
Conclusions: CVH was associated with transition from PD to death and from “Healthy” to Dementia/Death. In conclusion, poor CVH was directly associated with increased risk of mortality from PD into Death, Healthy into Dementia, and Healthy into Death.
