LATEBREAKER
Substance Use
The Association Between Outcomes of Naloxone Administration and Class of Substance Use Sunghyun* Sunghyun Chung
The Association Between Outcomes of Naloxone Administration and Class of Substance Use
Sunghyun Chung, MPH
Introduction
Point West Syringe Service Program is a harm reduction program based in Jefferson County, Colorado. Participants in this program may obtain new injection supplies, have access to safer sex supplies, counseling, and education materials, referrals for substance use and/or mental health support, and naloxone. This study conducted a descriptive analysis and cross-sectional investigation using the Point West Tracking System Data to examine the differences in outcomes of naloxone administration among participants based on the class of substances used.
Methods
A total of 311 naloxone administrations were examined who completed annual demographic and injection questionnaires and naloxone use reports. Outcomes of naloxone administration were classified as either mild (“survived, woke up with or without help) and severe (“paramedics came to naloxone user, or did not survive”). Drug classifications were opioids; opioid/stimulant combinations; opioid/depressant combinations; stimulants; or depressants. Logistic regression analysis was conducted to assess the relationship between substance class, poverty level, and Outcomes of naloxone administration.
Results
The majority of participants were males aged 30-39, predominantly White, followed by Hispanic/Latinx. Logistic regression showed that using opioid/depressant combinations (p=0.0243) and stimulants (p=0.0031) significantly predicted severe outcomes of naloxone administration, as did higher poverty levels (p=0.0073).
Conclusion
The class of substances used by participants significantly impacts the success of naloxone administrations. Opioid/Depressant Combination and Stimulant use, and a higher poverty level were identified as a significant factor contributing to severe outcomes of naloxone administration. This underscores the importance of tailoring harm reduction strategies to substance classes and addressing socioeconomic factors to enhance the effectiveness of Naloxone interventions.