First, through the Environmental Influences on Child Health Outcomes (ECHO) Study, the National Institutes of Health invested in harmonizing data from multiple existing pediatric cohorts to study early environmental exposures. Second, the Young Hearts Study (2021 onwards) is an ongoing pragmatic cohort of youth in the Chicago metropolitan area aiming to examine cardiovascular health trajectories and their interplay with social and environmental factors. Next, we will examine advances and challenges in measurement, including recent efforts to study mealtimes in young children and early life stressors. Finally, we will discuss interventions to improve cardiovascular health among youth. These studies will demonstrate the challenges of behavioral health interventions in youth and the important role of community engagement in developing such interventions. Attendees of this symposium will gain an understanding of ongoing progress in understanding factors that contribute to cardiovascular health in youth and modern efforts to improve it.