This symposium, Omics-Driven Approaches to Advance Precision Prevention of Chronic Diseases, will feature leading investigators applying diverse omics methods to illuminate pathways across a spectrum of conditions. Dr. Shilpa Bhupathiraju will present proteomic insights into cardiovascular disease, followed by Dr. Tengteng Wang to share recent findings on microbiome contributions to breast cancer. Dr. Matt Moll will highlight genetic and pharmacologic determinants of lung diseases, and Dr. Oana Zeleznik will discuss metabolomic signatures of incident persistent tinnitus. Dr. Cheng Peng will present transcriptomic predictors of cognitive decline and aging-related outcomes in cancer survivors. Collectively, these talks will demonstrate how integrative omics approaches deepen our understanding of disease mechanisms, identify novel biomarkers, and inform targeted prevention strategies. A moderated discussion will synthesize cross-cutting themes, addressing methodological challenges, causal inference, and translational potential. By bridging disciplines and data modalities, this symposium will highlight the promise of omics-driven science to advance next-generation precision prevention of chronic diseases.