Description: Only a decade ago, epigenetic marks were mainly studied by molecular biologists in cellular and animal models. However, with the realization that epigenetic marks can be modified and play pivotal roles in human health, many large human cohort studies are now attempting to generate epigenetic profiles for all members. The workshop will begin by introducing participants to epigenetics, including a brief overview of its relevance to human health and a review of key findings. Participants will then be introduced to the design, execution and interpretation of population-based epigenetic studies. Study execution will include an overview of measurement technologies and statistical analyses. Interpretation will cover techniques for uncovering the biological relevance of findings, including utilization of other molecular profiles such as gene expression. Participants will periodically be invited to complete ‘paper and pencil’ exercises to test comprehension.